What is menopause?

Menopause causes your body to undergo many changes.

Preparing for the changes and symptoms you can experience may be easier if you understand the process your body is going through.

Natural menopause occurs when:

  • Your ovaries naturally stop producing the hormones estrogen and progesterone
  • You go 12 consecutive months without having a period
  • No other biological or physiological cause can explain the missed periods

When does menopause begin?

Menopause begins at different times for different women, but most can expect it between the ages of 45 and 55. Whether you have reached menopause naturally or it has occurred due to surgery of the uterus and ovaries (called a hysterectomy and bilateral oophorectomy), this loss of estrogen can result in a variety of physical symptoms.

Common menopausal symptoms include hot flashes, night sweats, and vaginal symptoms that may vary in intensity. Bone loss may also occur as a result of the change in your body’s estrogen levels. When bone loss happens due to menopause, it can lead to osteoporosis.

A transition in 3 stages.

During this time of your life, your body usually moves through three gradual stages, unless your menopause is a result of surgery to remove your ovaries (bilateral oophorectomy), which ends the cycle immediately.

Perimenopause: Perimenopause is the time when estrogen production from your ovaries starts to decline and symptoms such as erratic periods, hot flashes, and vaginal dryness may begin. Most women reach this stage of the process in their late 40s.

Menopause: Menopause is identified by the passing of your final menstrual period. Of course, you will not be able to pinpoint your final period until you've been completely free from menstruation for some time. Once you've gone a full 12 months without having your period, count back to the time of your last period and that date is the date of your menopause. While the time of menopause is different from woman to woman, most begin between the ages of 45 and 55.

Postmenopause: Postmenopause is the stage of life after your final menstrual period.

It's important to talk to your doctor or other healthcare professional about the effects these changes may have on your body and your health.

Scroll for Important Safety Information and Indication

Do not use estrogens, with or without progestins, to prevent heart disease, heart attacks, strokes or dementia (decline in brain function). Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older.

Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.

You and your healthcare provider should talk regularly about whether you still need treatment with PREMPRO.

PREMPRO should not be used if you have unusual vaginal bleeding; have or had cancer; had a stroke or heart attack; have or had blood clots or liver problems; have a bleeding disorder; are allergic to any of its ingredients; or think you may be pregnant.

In a clinical trial, the most common side effects (>5%) that occurred with PREMPRO were vaginal bleeding, vaginitis due to yeast or other causes, painful menstruation, breast enlargement, breast pain, and leg cramps.

PREMPRO is used after menopause to reduce moderate to severe hot flashes; to treat moderate to severe dryness, itching, and burning, in and around the vagina; and to help reduce the chances of getting osteoporosis (thin weak bones).

If you are using or are considering using PREMPRO only to treat symptoms of vaginal dryness, consider topical therapies first. If you are using or are considering using PREMPRO only to prevent osteoporosis due to menopause, talk with your health care professional about whether a different treatment or medicine without estrogens might be better for you. PREMPRO should be used at the lowest effective dose and for the shortest duration consistent with your treatment goals and risks.

Please see Full Prescribing Information including Boxed Warning and Patient Information.